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王宜强

[日期:2016-10-25] 来源:  作者: [字体: ]

    从事科研25年来,在免疫学和实验血液学领域开展工作,目前以第一或通讯作者发表SCI论文30篇,非SCI期刊论文28篇。自2004年来主持国家自然科学基金四项、973前期研究专项一项、山东省自然科学杰出青年基金一项。特别是自2004年以来以眼部新生血管新生血管为模型,研究新生血管发生机制与防治策略;部分工作以中药单体或天然产物为研究对象,筛选对新生血管具有调控作用的中药成分。

    与新生血管或天然产物相关的15篇代表性研究论文和专利包括:

 1. Ren S, Qi X, Jia C, Wang Y (CA). Serum amyloid A and pairing formyl peptide receptor 2 are expressed in corneas and involved in inflammation-mediated neovascularization. International Journal of Ophthalmology 2014; 7(2):187-193

2. Yang X, Dong X, Jia C, Wang Y (CA). Profiling of genes associated with the murine model of oxygen-induced retinopathy. Molecular Vision 2013; 19:775-788

3. Chen P, Wang Ye, Yang L, Li C, Wang Yao, Xie L, Wang Y (CA). Novel bioactivity of NHERF1 in corneal neovascularization. Graefes Archive of Clinical and Experimental Ophthalmology 2012; 250:1615-1625

4. Li C, Li S, Jia C, Yang L, Song Z, Wang Y (CA). Low concentration of S100A8/9 promotes angiogenesis-related activity of vascular endothelial cells: bridges among inflammation, angiogenesis and tumorigenesis? Mediators of Inflammation 2012; 2012:248574. doi:10.1155/2012/248574

 5. Zhu W, Qi X, Ren S, Jia C, Song Z, Wang Y (CA). αA-crystallin in the pathogenesis and intervention of experimental murine corneal neovascularization. Experimental Eye Research 2012; 98:44-51

 6. Gong H, Wang Ye, Qi X, Wang C, Liu T, Ren S, Wang Y (CA). Differential response of lens crystallins and corneal crystallins in degenerative corneas. Experimental Eye Research 2012;96:55-64

7. Yang L, Zhou Q, Wang Yao, Gao Y, Wang Y (CA). Comparison of the therapeutic effects of extracts from Spirulina platensis and amnion membrane on inflammation-associated corneal neovascularization. International Journal of Ophthalmology 2012; 5(1):32-37

 8. Zhou Q, Yang L, Qu M, Wang Yao, Chen P, Wang Y, Shi W. Role of senescent fibroblasts on alkali-induced corneal neovascularization. Journal of Cellular Physiology 2012; 227(3): 1148-1156

 9. Jia C, Zhu W, Ren S, Xi H, Li S, Wang Y (CA). Comparison of genome-wide gene expression in suture- and alkali burn-induced murine corneal neovascularization. Molecular Vision 2011; 17:2386-2399

 10. Wang Ye, Yin H, Chen P, Xie L, Wang Y (CA). Inhibitory effect of canstatin in alkali-burn induced corneal neovascularization. Ophthalmic Research 2011; 46:66-72

11. Li C, Zhang F, Wang Y (CA). S100A Proteins in pathogenesis of experimental corneal neovascularization. Molecular Vision 2010; 16:2225-2235

12. Chen P, Yin H, Wang Y, Mi J, He W, Xie L, Wang Y (CA). Multi-gene targeted antiangiogenic therapies for experimental corneal neovascularization. Molecular Vision 2010; 16:310-319

 13. Yang L, Wang Y, Zhou Q, Chen P, Wang Y, Wang Y, Liu T, Xie L. Inhibitory effects of polysaccharides extract from Spirulina platensis on corneal neovascularization. Molecular Vision 2009; 15:1951-1961

14. Zhou Q, Wang Y, Yang L, Wang Y, Chen P, Wang Y, Dong X, Xie L. Histone deacetylase inhibitors blocked activation and caused senescence of corneal stromal cells. Molecular Vision 2008; 14:2556-2565

15. Liu D, Iruthayanathan M, Homan LL, Wang Y, Yang L, Wang Y, Dillon JS. Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through ERK 1/2-mediated mechanisms. Endocrinology 2008; 149(3):889-898

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