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戴克胜

[日期:2016-04-01] 来源:  作者: [字体: ]

戴克胜

 

医学博士,教授,博士生导师

 

 

 

 

获苏州大学博士学位,并在美国伊利诺大学从事博士后研究。2005年回国任北京航空航天大学“蓝天学者”特聘教授,主持血液与细胞生物学研究室工作。2011年至今,任苏州大学“特聘教授”,卫生部血栓与止血重点实验室副主任,2018年起,任“放射医学与辐射防护”国家重点实验室副主任。长期从事血栓与出血性疾病发病机制、血小板和微循环病生理功能调控机制、及相关疾病的诊治研究。主持国家自然科学基金重点项目、重点国际合作项目等多项国家级课题。研究成果在JCIPNASBloodCirc Res等国内外学术期刊发表论文一百余篇。2016年当选国际宇航科学院院士,入选教育部“新世纪优秀人才支持计划”、江苏省“双创团队”“医学领军人才”、“双创”人才、“姑苏卫生领军人才”,担任中国中西医结合学会微循环专业委员会主任委员,中国中西医结合学会痰瘀专业委员会副主任委员,世界中医药学会联合会气血专业委员会常务理事,中国病生理学会实验血液学专委会血管生物学组副组长,中华血液学分会血栓与止血学组委员,以及多个中英文杂志编委。

代表性论文:

1. Mengxing Chen, Rong Yan, Xiaodong Li, Yang Zhang, Chunliang Liu, Mengxiao Jiang, Honglei Ye, Xingjun Meng, Ningbo Pang, Lili Zhao, Jun Liu, Weiling Xiao, Renping Hu, Qingya Cui, Wei Zhong, Yunxiao Zhao, Mingqing Zhu, Anning Lin, Changgeng Ruan, Kesheng Dai*. Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia. PNAS. 2018 Oct.18, doi.org/10.1073/pnas.1808217115.

2. Lili Zhao, Jun Liu, Chunyan He, Rong Yan, Kangxi Zhou ,Qingya Cui, Xingjun Meng , Xiaodong Li,Yang Zhang , Yumei Nie, Yang Zhang, Renping Hu, Yancai Liu, Lian Zhao ,Mengxing Chen, Weiling Xiao, Jingluan Tian, Yunxiao Zhao, Lijuan Cao, Ling Zhou , Anning Lin, Changgeng Ruan, Kesheng Dai*. Protein kinase A determines platelet lifespan and survival by regulating apoptosis. Journal of Clinical Investigation. 2017, 127(12):4338-4351.

2. Yiwen Zhang, Jian Zhang, Rong Yan, Jingluan Tian, Yang Zhang, Jie Zhang, Mengxing Chen, Qingya Cui, Lili Zhao, Renping Hu, Miao Jiang, Zhenyu Li, Changgeng Ruan, Sudan He,  Kesheng Dai*. Receptorinteracting protein kinase 3 promotes platelet activation and thrombosis. PNAS. 2017, 114(11):2964-2969.

3. Lei Liu, Mengxing Chen, Lili Zhao, Qing Zhao, Renping Hu, Jie Zhu, Rong Yan, Kesheng Dai* . Ethanol Induces Platelet Apoptosis.Alcoholism: Clinical and Experimental Research. 2017, 41(2):291-298.

4. Qing Zhao, Ming Li, Mengxing Chen, Ling Zhou, Lili Zhao, Renping Hu, Rong Yan, Kesheng Dai*. Lovastatin induces platelet apoptosis. Environmental Toxicology and Pharmacology. 2016, 42:69-75.

5. Rong Yan, Na Ma, Mengxing Chen, Lili Zhao, Lijuan Cao, Yiwen Zhang, Jie Zhang, Ziqiang Yu, Zhaoyue Wang, Lijun Xia,Changgeng Ruan, Kesheng Dai*. Glycoprotein Iba clustering induces macrophage-mediated platelet clearance in the liver. Thrombosis and Haemostasis. 2015, 113(1):107-117.

6. Yicun Wu, Jin Dai, Weilin Zhang, Rong Yan, Yiwen Zhang, Changgeng Ruan, Kesheng Dai*. Arsenic trioxide induces platelet apoptosis. PLoS One. 2014, 9(1):e86445.

7. Jie zhang, Mengxing Chen, Yiwen Zhang, Lili Zhao, Yan Rong, Kesheng Dai*. Carmustine induces platelet apoptosis. Platelets. 2015, 26(5):437-442.

8. Ming Li, Zhaoyue Wang, Tongling Ma, Guoyuan Lu, Rong Yan, Lili Zhao, Kun Deng, Kesheng Dai*. Enhanced platelet apoptosis in chronic uremic patients. Renal Failure. 2014, 36(6):847-853.

9. Yanfang Pan, Tadayuki Yago, Jianxin Fu, Brett Herzog, J. Michael McDaniel, Padmaja Mehta-D’Souza, Xiaofeng Cai, Changgeng Ruan, Rodger P. McEver, Christopher West, Kesheng Dai, Hong Chen, Lijun Xia. Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets. Blood. 2014, 124(24):3656-3665.

10. Liumei Shou, Qiongyan Zhang, Wei Li, Xin Xie, Kai Chen, Lian Lian, Zhenyu Li, Feiran Gong, Kesheng Dai, Yixiang Mao, Min Tao. Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin. Oncol Rep. 2013, 30(3):1059-1066.    

11. Pingping Zhang, Juan Du, Lili Zhao, Xuejuan Wang, Yiwen Zhang, Rong Yan, Jin Dai,  Guanglei Liu, Feng Zhang, Kesheng Dai*. The role of intraplatelet reactive oxygen species in the regulation of platelet glycoprotein Ibα ectodomain shedding. Thrombosis Research. 2013,132(6):696-701.

12. Lili Zhao, Weilin Zhang, Mengxing Chen, Jiansheng Zhang, Mingyi Zhang, Kesheng Dai*. Aspirin induces platelet apoptosis. Platelets. 2013, 24(8):637-642.

13. Weilin Zhang, Lili Zhao, Jun Liu, Juan Du, Rong Yan, Kesheng Dai*. Role of 14-3-3ζ in Platelet Glycoprotein Ibα-von Willebrand Factor Interaction-Induced Signaling. International Journal of Molecular Sciences. 2012, 13(5):5364-5374.

14. Weilin Zhang, Lili Zhao, Jun Liu, Juan Du, Zhicheng Wang, Changgeng Ruan, Kesheng Dai*. Cisplatin induces platelet apoptosis through the ERK signaling pathway. Thrombosis Research. 2012, 13(1):81-91. 

15. Rong Yan, Xi Mo, Angel M. Paredes, Kesheng Dai, Francois Lanza, Miguel A. Cruz, Renhao Li. Reconstitution of the Platelet Glycoprotein Ib-IX Complex in Phospholipid Bilayer Nanodiscs. Biochemistry. 2011, 50(49):10598-10606.

16. Weilin Zhang, Jun Liu, Ruicheng Sui, Lili Zhao, Jun Du, Changgeng Ruan, Kesheng Dai*. Calpain Activator Dibucaine Induces Platelet Apoptosis. International Journal of Molecular Sciences. 2011, 12:2125-2137.

17. Suping Li, Zhicheng Wang, Yi Liao, Weilin Zhang, Quanwei Shi, Rong Yan, Changgeng Ruan, Kesheng Dai*. The glycoprotein Ibalpha-von Willebrand factor interaction induces platelet apoptosis. Journal of Thrombosis and Haemostasis. 2010, 8:341-350. 

18. Zhicheng Wang, Quanwei Shi, Rong Yan, Guanglei Liu, Weilin Zhang, Kesheng Dai*. The role of calpain in the regulation of ADAM17-dependent GPIbalpha ectodomain shedding. Archives of Biochemistry and Biophysics. 2010, 495:136-143. 

19. Suping Li, Quanwei Shi, Guanglei Liu, Weilin Zhang, Zhicheng Wang, Yuedan Wang, Kesheng Dai*. Mechanism of platelet functional changes and the effects of anti-platelet agents on in vivo hemostasis under different gravity conditions. Journal of Applied Physiology. 2010, 108:1241-1249. 

20. Zhicheng Wang, Quanwei Shi, Suping Li, Juan Du, Jun Liu, Kesheng Dai*. Hyperthermia induces platelet apoptosis and glycoprotein Ibα ectodomain shedding. Platelets. 2010, 21:229-237. 

21. Zhicheng Wang, Suping Li, Quanwei Shi, Rong Yan, Guanglei Liu, Kesheng Dai*. Calmodulin antagonists induce platelet apoptosis. Thrombosis Research. 2010, 125:340-350.

22. Guoming Li, Qiang Cheng, Kesheng Dai, Xiaofeng Zheng. The Ca2+-dependent multimerization of Homo sapiens S100 domain in Cornulin protects cells from injury. Progress in Biochemistry and Biophysics. 2010, 38(3):239-247.(e-pub ahead of print). 

23. Guoming Li, Linglong Qu,Geng Meng, Xiaoyun Bai, Kesheng Dai, Xiaofeng Zheng. Crystallization and preliminary X-ray crystallographic studies of human FAIM protein. Structural Biology and Crystallization Communications. 2010, F66:935-937. 

24. Yanhong Yuan, Weilin Zhang, Rong Yan, Yi Liao, Lili Zhao, Changgeng Ruan, Xiaoping Du, Kesheng Dai*. Identification of a novel 14-3-3ζ binding site within the cytoplasmic domain of platelet glycoprotein Ibα that plays a key role in regulating the VWF binding function of glycoprotein Ib-IX. Circulation Research. 2009, 105:1177-1185. 

25. Kesheng Dai*, Yuedan Wang, Rong Yan, Quanwei Shi, Zhicheng Wang, Yanhong Yuan, Hong Cheng, Suping Li, Yubo Fan, Fengyuan Zhuang. Effects of microgravity and hypergravity on platelet function. Thrombosis and Haemostasis. 2009, 101:902-910. (Cover, Editorial focus

26. Hong Cheng, Suping Li, Yanhong Yuan, Rong Yan, Changgeng Ruan, Kesheng Dai*. Shear-induced von Willebrand factor-dependent platelet glycoprotein Ibα shedding. The American Journal of Physiology-Heart and Circulatory Physiology. 2009, 297:H2128-2135. 

27. Rong Yan, Zhicheng Wang, Yanhong Yuan, Hong Cheng, Kesheng Dai*. Role of cAMP-dependent protein kinase in the regulation of platelet procoagulant activity. Archives of Biochemistry and Biophysics. 2009, 485:41-48. 

28. Suping Li, Quanwei Shi, Zhicheng Wang, Rong Yan, Hong Cheng, Kesheng Dai*. Hypergravity Results in Human Platelet Hyperactivity. Journal of Physiology and Biochemistry. 2009, 65:147-156. 

29. Rong Yan, Suping Li, Kesheng Dai*. The critical roles for cyclic AMP/cyclic AMP-dependent protein kinase in platelet physiology. Frontiers of Biology in China. 2009, 4:7-14. (Review)

30. Kesheng Dai*, Rong Yan, Suping Li, Yubo Fan, Fengyuan Zhuang, Changgeng Ruan. Prolonged inhibition of protein kinase A results in the dysfunction of platelet by GPIbα shedding. Thrombosis Research. 2009, 124:101-109. 

31. Guoming Li, Zhenting Tang, Geng Meng, Kesheng Dai, Jindong Zhao, Xiaofeng Zheng. Crystallization and preliminary X-ray crystallographic studies of O-methyltransferase from Anabaena PCC 7120. Acta Cryst Structural Biology and Crystallization Communications. 2009, F65:1039-1041. 

32. Kesheng Dai, Richard J. Bodnar, Michael C. Berndt, Xiaoping Du. A critical role for 14-3-3 protein in platelet adhesion and its therapeutic implications. Blood. 2005, 106:1975-1981. 

33. Kesheng Dai, Huaiping Zhu, Changgeng Ruan. Construction, expression and characterization of a single chain Fv specific against platelets GP Ibα. Thrombosis Research. 2003, 109:137-144. 

34. Kesheng Dai, Weiqing Gao, Changgeng Ruan. The Sma I polymorphism in the von Willebrand factor gene associated with acute ischemic stroke. Thrombosis Research. 2001, 104:389-395. 

 

 

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E-mail: kdai@suda.edu.cn

 

 

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