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吴剑波

[日期:2016-04-01] 来源:  作者: [字体: ]

吴剑波,男,研究员,德国乌尔姆大学医学博士学位。美国密苏里州立大学Columbia校区生物医学科学部,Dalton 心血管研究中心和医学院心血管内科做博士后研究、美国密苏理州立大学研究助理教授。现任西南医科大学药物与功能性食品研究中心主任。主要从事血管生成、血栓形成、肿瘤转移微环境的研究目前担任国际生物医学杂志Current AngiogenesisFrontiers in Vascular PhysiologyClinical Cardiovascular Drugs编委和多家国际主要杂志包括ATVBAtherosclerosisJournal of Cellular Biochemistry 的特邀审稿人。现主持国家自然科学基金面上项目、四川省教育厅创新团队、教育部留学归国人员等项目。

 

主要研究方向:

血管生成、血栓形成的机制与干预、肿瘤转移微环境的研究。 

 

主要在研课题:

1.    2012-2015,国家自然基金面上项目,项目名称:PAI-1在肿瘤新生血管形成中对血管稳定性的作用及机制研究 (81172050), 项目负责人。

2.    2016-2019,国家自然基金面上项目,项目名称:PAI-1及其糖基化玻连蛋白在糖尿病血管重构的作用和机制 (81570263), 项目负责人。

 

近年发表的主要论文:

 

1.      Xiao L, Yan K, Yang Y, Chen N, Li Y, Deng X, Wang L, Liu Y, Mu L, Li R, Luo M, Ren M, Wu J*. Anti-vascular endothelial growth factor treatment induces blood flow recovery through vascular remodeling in high-fat diet induced diabetic mice. Microvasc Res. 2016; 105: 70. ( *, as corresponding author).

2.      Hong K, Lee S, Li R, Yang Y, Tanner MA, Wu J, Hill MA. Adiponectin Receptor Agonist, AdipoRon, Causes Vasorelaxation Predominantly Via a Direct Smooth Muscle Action. Microcirculation. 2016 Jan 5. doi: 10.1111/micc.12266. [Epub ahead of print]

 

3.      Chen N, Ren M, Li R, Deng X, Li Y, Yan K, Xiao L, Yang Y, Wang L, Luo M, Fay WP, Wu J*. Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma.

Mol Cancer. 2015;14:140. 

 

4.      Wang L, Zhang X, Pang L, Xiao L, Li Y, Chen N, Ren M, Deng X, Wu J*. Glycation of Vitronectin Inhibits VEGF-induced Angiogenesis by Uncoupling VEGF Receptor-2-αvβ3 Integrin Cross-talk. Cell Death Dis. 2015 ;6:e1796.

 

5.      Luo M, Li R, Deng X, Ren M, Chen N, Zeng M, Yan K, Xia J, Liu F, Ma W, Yang Y, Wan Q, Wu J* . Platelet-derived miR-103b as a novel biomarker for the early diagnosis of type 2 diabetes. Acta Diabetol. 2015;52(5):943-9. 

 

6.      Wu J*, Strawn TL, Luo M, Wang L, Li R, Ren M, Xia J, Zhang Z, Ma W, Luo T, Lawrence DA, Fay WP. Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-αVβ3 integrin cross talk. Arterioscler Thromb Vasc Biol. 2015;35(1):111-120.

 

7.      Ren M, Li R, Luo M, Chen N, Deng X, Yan K, Zeng M, Wu J*. Endothelial cells but not platelets are the major source of Toll-like receptor 4 in the arterial thrombosis and tissue factor expression in mice. Am J Physiol. 2014;307(7):R901-907.

 

8.      Li R. Luo M. Ren M. Chen N. Xia J. Deng X. Zeng M. Yan K. Luo T. Wu J*.  Vitronectin regulation of vascular endothelial growth factor-mediated angiogenesis.  J Vasc Res. 2014; 51:110-117.

 

9.       Li R, Ren M, Chen N , Luo M, Deng X, Xia J, Yu G, Liu J, He B, Zhang X, Zhang Z, Zhang X, Ran B and Wu J*. Presence of intratumoral platelets is associated with tumor vessel structure and metastasis. BMC Cancer  2014; 14:167.

 

10.  Zhang Z, Yang Y, Hill MA, Wu J*. Does C-reactive protein contribute to atherothrombosis via oxidant-mediated release of pro-thrombotic factors and activation of platelets?  Front Physiol. 2012;3:433.

 

11.  Li R, Ren M, Chen N, Luo M, Zhang Z, Wu J*. Vitronectin increases vascular permeability by promoting VE-cadherin internalization at cell junctions.  PLoS One. 2012;7(5):e37195.

 

12.  Li R, Ren M, Luo M, Chen N, Zhang Z, Luo B, Wu J*.  Monomeric C-reactive protein alters fibrin clot properties on endothelial cells.  Thromb Res. 2012;129(5):e251-6.

 

13.  Garg N, Goyal N, Strawn TL, Wu J, Mann KM, Lawrence DA, Fay WP.  Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices. 

       J Thromb Haemost. 2010; 8: 1847-1854.

 

14.  Yang Y, Wu X, Gui P, Wu J, Sheng JZ, Ling S, Braun P, Davis GE, Davis MJ.  α5β1 integrin engagement increases BK channel current and Ca2+ sensitivity through c-Src mediated channel phosphorylation.  J Biol Chem. 2010 285(1):131-141. 

 

15.  Wu J*, Peng L, McMahon GA, Rabbani AB, Lawrence DA, Fay WP.  Recombinant plasminogen activator Inhibitor-1 inhibits intimal hyperplasia.    Arterioscler Thromb Vasc Biol. 2009; 29(10):1565-1570.

 

16.  Hyder SM, Liang Y, Wu J.   Estrogen regulation of thrombospondin-1 in human breast cancer cells.     Int. J. Cancer   2009; 125(5):1045-1053.

 

17.  Hyder SM, Liang Y, Wu J, and Welbern V.   Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells.  Endocr Relat Cancer.  2009;16(3):809-817.

 

18.  Wu J*, Stevenson MJ, Brown JM, Grunz EA, Strawn TL, Fay WP.   C-reactive protein enhances tissue factor expression by vascular smooth muscle cells: mechanisms and in vivo significance.    Arterioscler Thromb Vasc Biol. 2008; 28(4):698-704. Editorial comment.   

 

19.  Zhou W, Liu Z, Wu J, Liu J, Hyder SM, Antoniou E, Lubahn DB.  Identification and transcriptional activity characterization of two novel splicing isoforms of human ERRβ.  

Journal of Clinical Endocrinology & Metabolism   2006; 91(2):569-579.

 

20.  Wu J, Liang Y, Nawaz Z, and Hyder SM. Complex agonist-like properties of ICI 182,780 (Faslodex) in human breast cancer cells that predominantly express progesterone receptor-B: Implications for treatment resistance.  International Journal of Oncology   2005; 27(6): 1647-1659.

 

21.  Wu J, Brandt S, Hyder SM. Ligand- and cell-specific effects of signal transduction pathway inhibitors on progestin-induced vascular endothelial growth factor levels in human breast cancer cells.  Molecular Endocrinology   2005; 19(2):312-326.

 

22.  Liang Y, Wu J, Hyder SM.  Progestins regulation of VEGF in mammary cancer cell: A connection to tumor suppressor p53.   J Steroid Biochem Mol Biol. 2005; 93(2-5):173-182.

 

23.  Wu J, Richer J, Horwitz KB and Hyder SM.  Progestin-dependent induction of VEGF in human breast cancer cells: preferential regulation by progesterone receptor B. 

     Cancer Research   2004; 64(6): 2238-2244.

 

24.  Babiak A, Schumm AM, Wangler, C, Loukas M, Wu J, Dombrowski S, Matuschek C, Kotzerke J, Dehio C, Waltenberger J.  Coordinated activation of VEGFR-1 and VEGFR-2 is a potent arteriogenic stimulus leading to enhancement of regional perfusion.  Cardiovascular Research 2004; 61(4):789-795.

 

 

 

 

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